Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a dynamin inhibitor of moderate potency (IC50 ˜ 15 μM in vitro). We show that dynasore binds stoichiometrically to detergent...

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Bibliographic Details
Main Authors: McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian‐Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A., Robinson, Phillip J.
Format: Online
Language:English
Published: John Wiley & Sons A/S 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138991/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138991/

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