Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses

Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive streng...

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Main Authors:	Hu, Gangfeng, Wang, Hui, Yao, Xiaocong, Bi, Dawei, Zhu, Gang, Tang, Songchao, Wei, Jie, Yang, Lili, Tong, Peijian, Xiao, Luwei
Format:	Online
Language:	English
Published:	Dove Medical Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138000/

id	pubmed-4138000
recordtype	oai_dc
spelling	pubmed-41380002014-08-20 Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses Hu, Gangfeng Wang, Hui Yao, Xiaocong Bi, Dawei Zhu, Gang Tang, Songchao Wei, Jie Yang, Lili Tong, Peijian Xiao, Luwei Original Research Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants. Dove Medical Press 2014-08-11 /pmc/articles/PMC4138000/ /pubmed/25143735 http://dx.doi.org/10.2147/IJN.S65682 Text en © 2014 Hu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hu, Gangfeng Wang, Hui Yao, Xiaocong Bi, Dawei Zhu, Gang Tang, Songchao Wei, Jie Yang, Lili Tong, Peijian Xiao, Luwei
spellingShingle	Hu, Gangfeng Wang, Hui Yao, Xiaocong Bi, Dawei Zhu, Gang Tang, Songchao Wei, Jie Yang, Lili Tong, Peijian Xiao, Luwei Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
author_facet	Hu, Gangfeng Wang, Hui Yao, Xiaocong Bi, Dawei Zhu, Gang Tang, Songchao Wei, Jie Yang, Lili Tong, Peijian Xiao, Luwei
author_sort	Hu, Gangfeng
title	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_short	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_full	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_fullStr	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_full_unstemmed	Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
title_sort	development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses
description	Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants.
publisher	Dove Medical Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138000/
_version_	1613125548699025408

Development of nanofluorapatite polymer-based composite for bioactive orthopedic implants and prostheses

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