Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here...

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Main Authors:	Sundquist, Jan, Sundquist, Kristina, Ji, Jianguang
Format:	Online
Language:	English
Published:	eLife Sciences Publications, Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135348/

id	pubmed-4135348
recordtype	oai_dc
spelling	pubmed-41353482014-08-22 Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders Sundquist, Jan Sundquist, Kristina Ji, Jianguang Epidemiology and Global Health Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34–1.44) and 2.19 (95% CI 2.15–2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36–1.58) and 2.70 (95% CI 2.59–2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed. eLife Sciences Publications, Ltd 2014-08-19 /pmc/articles/PMC4135348/ /pubmed/25139954 http://dx.doi.org/10.7554/eLife.02917 Text en Copyright © 2014, Sundquist et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sundquist, Jan Sundquist, Kristina Ji, Jianguang
spellingShingle	Sundquist, Jan Sundquist, Kristina Ji, Jianguang Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
author_facet	Sundquist, Jan Sundquist, Kristina Ji, Jianguang
author_sort	Sundquist, Jan
title	Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
title_short	Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
title_full	Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
title_fullStr	Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
title_full_unstemmed	Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
title_sort	autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
description	Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34–1.44) and 2.19 (95% CI 2.15–2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36–1.58) and 2.70 (95% CI 2.59–2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.
publisher	eLife Sciences Publications, Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135348/
_version_	1613125090918006784

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

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