Positive Feedback Promotes Oscillations in Negative Feedback Loops

A simple three-component negative feedback loop is a recurring motif in biochemical oscillators. This motif oscillates as it has the three necessary ingredients for oscillations: a three-step delay, negative feedback, and nonlinearity in the loop. However, to oscillate, this motif under the common G...

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Bibliographic Details
Main Authors: Ananthasubramaniam, Bharath, Herzel, Hanspeter
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134231/