General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels

The pore-lining helix (PLH) bundles are central to the function of all ion channels, as their conformational rearrangements dictate channel gating. Here we explore all plausible oligomeric arrangements of the PLH bundles within homomeric ion channels by building models using generic restraints. In p...

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Bibliographic Details
Main Authors: Dai, Jian, Zhou, Huan-Xiang
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133698/