Variation in the Fitness Effects of Mutations with Population Density and Size in Escherichia coli

The fitness effects of mutations are context specific and depend on both external (e.g., environment) and internal (e.g., cellular stress, genetic background) factors. The influence of population size and density on fitness effects are unknown, despite the central role population size plays in the s...

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Bibliographic Details
Main Authors: Cao, Huansheng, Butler, Kevin, Hossain, Mithi, Lewis, James D.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133409/