The Pathogenesis of Lupus Nephritis
Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus nephritis examines the ro...
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| Format: | Online |
| Language: | English |
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2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131745/ |
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pubmed-41317452014-08-14 The Pathogenesis of Lupus Nephritis Sterner, Rosalie M. Hartono, Stella P. Grande, Joseph P. Article Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus nephritis examines the role of the complement cascade; the significance of autoantibodies, the breaking of tolerance, and the implications of altered apoptosis in breaking tolerance; and the contributions of adaptive immunity and cross-talk with the innate immune system in driving renal damage. Delineation of basic mechanisms underlying the development of acute and chronic renal damage in lupus nephritis can result in the continued development of more specific and effective treatments. 2014-04 /pmc/articles/PMC4131745/ /pubmed/25133068 http://dx.doi.org/10.4172/2155-9899.1000205 Text en Copyright: © 2014 Sterner RM, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sterner, Rosalie M. Hartono, Stella P. Grande, Joseph P. |
| spellingShingle |
Sterner, Rosalie M. Hartono, Stella P. Grande, Joseph P. The Pathogenesis of Lupus Nephritis |
| author_facet |
Sterner, Rosalie M. Hartono, Stella P. Grande, Joseph P. |
| author_sort |
Sterner, Rosalie M. |
| title |
The Pathogenesis of Lupus Nephritis |
| title_short |
The Pathogenesis of Lupus Nephritis |
| title_full |
The Pathogenesis of Lupus Nephritis |
| title_fullStr |
The Pathogenesis of Lupus Nephritis |
| title_full_unstemmed |
The Pathogenesis of Lupus Nephritis |
| title_sort |
pathogenesis of lupus nephritis |
| description |
Lupus nephritis is a serious potential feature of systemic lupus erythematous (SLE). Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to end-stage kidney or cardiovascular damage. This review of the pathogenesis of lupus nephritis examines the role of the complement cascade; the significance of autoantibodies, the breaking of tolerance, and the implications of altered apoptosis in breaking tolerance; and the contributions of adaptive immunity and cross-talk with the innate immune system in driving renal damage. Delineation of basic mechanisms underlying the development of acute and chronic renal damage in lupus nephritis can result in the continued development of more specific and effective treatments. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131745/ |
| _version_ |
1613123938838118400 |