New benzene derivatives from cultures of ascomycete Daldinia concentrica

Three new benzene derivatives, named daldins A-C (1–3), together with a known analogue, 2-hydroxymethyl-3-(1-hydroxypropyl) phenol (4) have been isolated from cultures of ascomycete Daldinia concentrica. The structures of 1–4 with absolute configuration were established by means of spectroscopic met...

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Bibliographic Details
Main Authors: Feng, Tao, Li, Zheng-Hui, Yin, Xia, Dong, Ze-Jun, Wang, Gang-Qiang, Li, Xing-Yao, Li, Yan, Liu, Ji-Kai
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131580/
Description
Summary:Three new benzene derivatives, named daldins A-C (1–3), together with a known analogue, 2-hydroxymethyl-3-(1-hydroxypropyl) phenol (4) have been isolated from cultures of ascomycete Daldinia concentrica. The structures of 1–4 with absolute configuration were established by means of spectroscopic methods and X-ray diffraction. All compounds showed no significant inhibition on five human cancer cell lines with IC50 values > 40 μmol.