Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells

Disruption of HPV16-E7 by CRISPR/Cas System Induces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical Cancer Cells

High-risk human papillomavirus (HR-HPV) has been recognized as a major causative agent for cervical cancer. Upon HPV infection, early genes E6 and E7 play important roles in maintaining malignant phenotype of cervical cancer cells. By using clustered regularly interspaced short palindromic repeats-...

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Bibliographic Details
Main Authors: Hu, Zheng, Yu, Lan, Zhu, Da, Ding, Wencheng, Wang, Xiaoli, Zhang, Changlin, Wang, Liming, Jiang, Xiaohui, Shen, Hui, He, Dan, Li, Kezhen, Xi, Ling, Ma, Ding, Wang, Hui
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127252/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127252/

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