The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177
NO production catalysed by eNOS (endothelial nitric-oxide synthase) plays an important role in the cardiovascular system. A variety of agonists activate eNOS through the Ser1177 phosphorylation concomitant with Thr495 dephosphorylation, resulting in increased ·NO production with a basal level of cal...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122979/ |