Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan

Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan

Background and Objective: Breakpoint cluster region-Abelson (BCR-ABL) rearrangement or Philadelphia (Ph) chromosome in Chronic Myeloid Leukemia (CML) is derived from a reciprocal chromosomal translocation between ABL gene on chromosome 9 and BCR gene on chromosome 22. This chimeric protein has vari...

Full description

Bibliographic Details
Main Authors: Tabassum, Najia, Saboor, Mohammad, Ghani, Rubina, Moinuddin, Moinuddin
Format: Online
Language:English
Published: Professional Medical Publicaitons 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121711/
id pubmed-4121711
recordtype oai_dc
spelling pubmed-41217112014-08-05 Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan Tabassum, Najia Saboor, Mohammad Ghani, Rubina Moinuddin, Moinuddin Original Article Background and Objective: Breakpoint cluster region-Abelson (BCR-ABL) rearrangement or Philadelphia (Ph) chromosome in Chronic Myeloid Leukemia (CML) is derived from a reciprocal chromosomal translocation between ABL gene on chromosome 9 and BCR gene on chromosome 22. This chimeric protein has various sizes and therefore different clinical behaviour. The purpose of this study was to determine the heterogeneity of BCR-ABL rearrangement in patients with Ph+CML in Pakistan. Professional Medical Publicaitons 2014 /pmc/articles/PMC4121711/ /pubmed/25097530 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Tabassum, Najia
Saboor, Mohammad
Ghani, Rubina
Moinuddin, Moinuddin
spellingShingle Tabassum, Najia
Saboor, Mohammad
Ghani, Rubina
Moinuddin, Moinuddin
Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
author_facet Tabassum, Najia
Saboor, Mohammad
Ghani, Rubina
Moinuddin, Moinuddin
author_sort Tabassum, Najia
title Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
title_short Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
title_full Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
title_fullStr Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
title_full_unstemmed Heterogeneity of BCR-ABL rearrangement in patients with chronic myeloid leukemia in Pakistan
title_sort heterogeneity of bcr-abl rearrangement in patients with chronic myeloid leukemia in pakistan
description Background and Objective: Breakpoint cluster region-Abelson (BCR-ABL) rearrangement or Philadelphia (Ph) chromosome in Chronic Myeloid Leukemia (CML) is derived from a reciprocal chromosomal translocation between ABL gene on chromosome 9 and BCR gene on chromosome 22. This chimeric protein has various sizes and therefore different clinical behaviour. The purpose of this study was to determine the heterogeneity of BCR-ABL rearrangement in patients with Ph+CML in Pakistan.
publisher Professional Medical Publicaitons
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121711/
_version_ 1613120905086500864

Similar Items