Adult adipose-derived stem cells and breast cancer: a controversial relationship

Breast cancer is the most common cancer in women and autologous fat grafting is an important clinical application in treatment of post-surgical deformities. The simplicity of fat grafting procedures and the absence of subsequent visible scar prompted an increasing interest for this technique. The pl...

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Main Authors:	Bielli, Alessandra, Scioli, Maria Giovanna, Gentile, Pietro, Agostinelli, Sara, Tarquini, Chiara, Cervelli, Valerio, Orlandi, Augusto
Format:	Online
Language:	English
Published:	Springer International Publishing 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117859/

id	pubmed-4117859
recordtype	oai_dc
spelling	pubmed-41178592014-08-01 Adult adipose-derived stem cells and breast cancer: a controversial relationship Bielli, Alessandra Scioli, Maria Giovanna Gentile, Pietro Agostinelli, Sara Tarquini, Chiara Cervelli, Valerio Orlandi, Augusto Review Breast cancer is the most common cancer in women and autologous fat grafting is an important clinical application in treatment of post-surgical deformities. The simplicity of fat grafting procedures and the absence of subsequent visible scar prompted an increasing interest for this technique. The plasticity of adipose-derived stem cells (ASCs) obtained from stromal vascular fraction (SVF) of adult adipose tissue provided exciting perspectives for regenerative medicine and surgery. The recent discovery that SVF/ASC enrichment further ameliorates clinical efficacy of grafting ASCs suggest as ASC-mediated new adipogenesis and vasculogenesis. ASC adipogenic differentiation involves Akt activity and EGFRs, FGFRs, ERbB2 receptor-mediated pathways that also play a pivotal role in the regulation of breast cancer growth. Moreover, the finding that platelet-derived growth factors and hormones improved long-term maintenance of fat grafting raises new concerns for their use during breast reconstruction after cancer surgery. However, it remains unclear whether grafted or resident ASCs may increase the risk of de novo cancer development or recurrence. Preliminary follow-up studies seem to support the efficacy and safety of SVF/ASCs enrichment and the additional benefit from the combined use of autologous platelet-derived growth factors and hormones during breast reconstruction procedures. In the present review we highlighted the complex interplay between resident or grafted ASCs, mature adipocytes, dormant or active breast cancer cells and tumor microenvironment. Actually, data concerning the permissive role of ASCs on breast cancer progression are contrasting, although no clear evidence speaking against their use exists. Springer International Publishing 2014-07-08 /pmc/articles/PMC4117859/ /pubmed/25089245 http://dx.doi.org/10.1186/2193-1801-3-345 Text en © Bielli et al.; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bielli, Alessandra Scioli, Maria Giovanna Gentile, Pietro Agostinelli, Sara Tarquini, Chiara Cervelli, Valerio Orlandi, Augusto
spellingShingle	Bielli, Alessandra Scioli, Maria Giovanna Gentile, Pietro Agostinelli, Sara Tarquini, Chiara Cervelli, Valerio Orlandi, Augusto Adult adipose-derived stem cells and breast cancer: a controversial relationship
author_facet	Bielli, Alessandra Scioli, Maria Giovanna Gentile, Pietro Agostinelli, Sara Tarquini, Chiara Cervelli, Valerio Orlandi, Augusto
author_sort	Bielli, Alessandra
title	Adult adipose-derived stem cells and breast cancer: a controversial relationship
title_short	Adult adipose-derived stem cells and breast cancer: a controversial relationship
title_full	Adult adipose-derived stem cells and breast cancer: a controversial relationship
title_fullStr	Adult adipose-derived stem cells and breast cancer: a controversial relationship
title_full_unstemmed	Adult adipose-derived stem cells and breast cancer: a controversial relationship
title_sort	adult adipose-derived stem cells and breast cancer: a controversial relationship
description	Breast cancer is the most common cancer in women and autologous fat grafting is an important clinical application in treatment of post-surgical deformities. The simplicity of fat grafting procedures and the absence of subsequent visible scar prompted an increasing interest for this technique. The plasticity of adipose-derived stem cells (ASCs) obtained from stromal vascular fraction (SVF) of adult adipose tissue provided exciting perspectives for regenerative medicine and surgery. The recent discovery that SVF/ASC enrichment further ameliorates clinical efficacy of grafting ASCs suggest as ASC-mediated new adipogenesis and vasculogenesis. ASC adipogenic differentiation involves Akt activity and EGFRs, FGFRs, ERbB2 receptor-mediated pathways that also play a pivotal role in the regulation of breast cancer growth. Moreover, the finding that platelet-derived growth factors and hormones improved long-term maintenance of fat grafting raises new concerns for their use during breast reconstruction after cancer surgery. However, it remains unclear whether grafted or resident ASCs may increase the risk of de novo cancer development or recurrence. Preliminary follow-up studies seem to support the efficacy and safety of SVF/ASCs enrichment and the additional benefit from the combined use of autologous platelet-derived growth factors and hormones during breast reconstruction procedures. In the present review we highlighted the complex interplay between resident or grafted ASCs, mature adipocytes, dormant or active breast cancer cells and tumor microenvironment. Actually, data concerning the permissive role of ASCs on breast cancer progression are contrasting, although no clear evidence speaking against their use exists.
publisher	Springer International Publishing
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117859/
_version_	1613119672791597056

Adult adipose-derived stem cells and breast cancer: a controversial relationship

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