Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine...

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Bibliographic Details
Main Authors: Kim, Eun-Young, Lorenzo-Redondo, Ramon, Little, Susan J., Chung, Yoon-Seok, Phalora, Prabhjeet K., Maljkovic Berry, Irina, Archer, John, Penugonda, Sudhir, Fischer, Will, Richman, Douglas D., Bhattacharya, Tanmoy, Malim, Michael H., Wolinsky, Steven M.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117599/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117599/

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