Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia

Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizo...

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Main Authors:	Sohn, Hoyoung, Kim, Borah, Kim, Keun Hyang, Kim, Min-Kyoung, Choi, Tai Kiu, Lee, Sang-Hyuk
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117506/

id	pubmed-4117506
recordtype	oai_dc
spelling	pubmed-41175062014-08-04 Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia Sohn, Hoyoung Kim, Borah Kim, Keun Hyang Kim, Min-Kyoung Choi, Tai Kiu Lee, Sang-Hyuk Research Article Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic resonance scans for gray matter (GM) and white matter (WM) analysis, and genotype analysis for VRK2 rs2312147, were conducted. The Positive and Negative Syndrome Scale and the Digit Symbol Test were assessed for schizophrenia patients. There was no significant difference in either GM volume or WM connectivity with regard to rs2312147 genotype in healthy subjects. In contrast, we found significant differences in the WM connectivity between rs2312147 CC and CT/TT genotype groups of schizophrenia patients. The related brain areas included the splenium of corpus callosum, the left occipital lobe WM, the internal capsule (left anterior limb and right retrolenticular part), the bilateral temporal lobe WM, the left fornix/stria terminalis, the left cingulate gyrus WM, and the left parietal lobe WM. Voxelwise correlation analysis revealed that the Digit Symbol Test scores (age corrected) correlated with the fractional anisotropy in WM tracts that previously showed significant group differences between the CT/TT and CC genotypes in the rs2312147 CT/TT genotype group, while no significant correlation was found in the CC genotype group. Our data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia. Public Library of Science 2014-07-31 /pmc/articles/PMC4117506/ /pubmed/25079070 http://dx.doi.org/10.1371/journal.pone.0103519 Text en © 2014 Sohn et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sohn, Hoyoung Kim, Borah Kim, Keun Hyang Kim, Min-Kyoung Choi, Tai Kiu Lee, Sang-Hyuk
spellingShingle	Sohn, Hoyoung Kim, Borah Kim, Keun Hyang Kim, Min-Kyoung Choi, Tai Kiu Lee, Sang-Hyuk Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
author_facet	Sohn, Hoyoung Kim, Borah Kim, Keun Hyang Kim, Min-Kyoung Choi, Tai Kiu Lee, Sang-Hyuk
author_sort	Sohn, Hoyoung
title	Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
title_short	Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
title_full	Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
title_fullStr	Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
title_full_unstemmed	Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
title_sort	effects of vrk2 (rs2312147) on white matter connectivity in patients with schizophrenia
description	Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic resonance scans for gray matter (GM) and white matter (WM) analysis, and genotype analysis for VRK2 rs2312147, were conducted. The Positive and Negative Syndrome Scale and the Digit Symbol Test were assessed for schizophrenia patients. There was no significant difference in either GM volume or WM connectivity with regard to rs2312147 genotype in healthy subjects. In contrast, we found significant differences in the WM connectivity between rs2312147 CC and CT/TT genotype groups of schizophrenia patients. The related brain areas included the splenium of corpus callosum, the left occipital lobe WM, the internal capsule (left anterior limb and right retrolenticular part), the bilateral temporal lobe WM, the left fornix/stria terminalis, the left cingulate gyrus WM, and the left parietal lobe WM. Voxelwise correlation analysis revealed that the Digit Symbol Test scores (age corrected) correlated with the fractional anisotropy in WM tracts that previously showed significant group differences between the CT/TT and CC genotypes in the rs2312147 CT/TT genotype group, while no significant correlation was found in the CC genotype group. Our data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117506/
_version_	1613119552630030336

Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia

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