HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties

HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties

HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes....

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Main Authors: Ciminale, Vincenzo, Rende, Francesca, Bertazzoni, Umberto, Romanelli, Maria G.
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114287/
id pubmed-4114287
recordtype oai_dc
spelling pubmed-41142872014-08-12 HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties Ciminale, Vincenzo Rende, Francesca Bertazzoni, Umberto Romanelli, Maria G. Neuroscience HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed. Frontiers Media S.A. 2014-07-29 /pmc/articles/PMC4114287/ /pubmed/25120538 http://dx.doi.org/10.3389/fmicb.2014.00398 Text en Copyright © 2014 Ciminale, Rende, Bertazzoni and Romanelli. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
spellingShingle Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
author_facet Ciminale, Vincenzo
Rende, Francesca
Bertazzoni, Umberto
Romanelli, Maria G.
author_sort Ciminale, Vincenzo
title HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_short HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_full HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_fullStr HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_full_unstemmed HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
title_sort htlv-1 and htlv-2: highly similar viruses with distinct oncogenic properties
description HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.
publisher Frontiers Media S.A.
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114287/
_version_ 1613118833461035008

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