Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?

Understanding the mechanisms underlying the pathophysiology of cerebral malaria in patients with Plasmodium falciparum infection is necessary to implement new curative interventions. While autopsy-based studies shed some light on several pathological events that are believed to be crucial in the dev...

Full description

Bibliographic Details
Main Authors:	Mohanty, Sanjib, Taylor, Terrie E, Kampondeni, Sam, Potchen, Mike J, Panda, Premanand, Majhi, Megharay, Mishra, Saroj K, Wassmer, Samuel C
Format:	Online
Language:	English
Published:	BioMed Central 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114090/

id	pubmed-4114090
recordtype	oai_dc
spelling	pubmed-41140902014-07-30 Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis? Mohanty, Sanjib Taylor, Terrie E Kampondeni, Sam Potchen, Mike J Panda, Premanand Majhi, Megharay Mishra, Saroj K Wassmer, Samuel C Review Understanding the mechanisms underlying the pathophysiology of cerebral malaria in patients with Plasmodium falciparum infection is necessary to implement new curative interventions. While autopsy-based studies shed some light on several pathological events that are believed to be crucial in the development of this neurologic syndrome, their investigative potential is limited and has not allowed the identification of causes of death in patients who succumb to it. This can only be achieved by comparing features between patients who die from cerebral malaria and those who survive. In this review, several alternative approaches recently developed to facilitate the comparison of specific parameters between fatal, non-fatal cerebral malaria and uncomplicated malaria patients are described, as well as their limitations. The emergence of neuroimaging as a revolutionary tool in identifying critical structural and functional modifications of the brain during cerebral malaria is discussed and highly promising areas of clinical research using magnetic resonance imaging are highlighted. BioMed Central 2014-07-18 /pmc/articles/PMC4114090/ /pubmed/25038815 http://dx.doi.org/10.1186/1475-2875-13-276 Text en Copyright © 2014 Mohanty et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mohanty, Sanjib Taylor, Terrie E Kampondeni, Sam Potchen, Mike J Panda, Premanand Majhi, Megharay Mishra, Saroj K Wassmer, Samuel C
spellingShingle	Mohanty, Sanjib Taylor, Terrie E Kampondeni, Sam Potchen, Mike J Panda, Premanand Majhi, Megharay Mishra, Saroj K Wassmer, Samuel C Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
author_facet	Mohanty, Sanjib Taylor, Terrie E Kampondeni, Sam Potchen, Mike J Panda, Premanand Majhi, Megharay Mishra, Saroj K Wassmer, Samuel C
author_sort	Mohanty, Sanjib
title	Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
title_short	Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
title_full	Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
title_fullStr	Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
title_full_unstemmed	Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
title_sort	magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?
description	Understanding the mechanisms underlying the pathophysiology of cerebral malaria in patients with Plasmodium falciparum infection is necessary to implement new curative interventions. While autopsy-based studies shed some light on several pathological events that are believed to be crucial in the development of this neurologic syndrome, their investigative potential is limited and has not allowed the identification of causes of death in patients who succumb to it. This can only be achieved by comparing features between patients who die from cerebral malaria and those who survive. In this review, several alternative approaches recently developed to facilitate the comparison of specific parameters between fatal, non-fatal cerebral malaria and uncomplicated malaria patients are described, as well as their limitations. The emergence of neuroimaging as a revolutionary tool in identifying critical structural and functional modifications of the brain during cerebral malaria is discussed and highly promising areas of clinical research using magnetic resonance imaging are highlighted.
publisher	BioMed Central
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114090/
_version_	1613118767747825664

Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis?

Similar Items