Gigantism caused by growth hormone secreting pituitary adenoma

Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression wa...

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Main Authors: Rhee, Noorisaem, Jeong, Kumi, Yang, Eun Mi, Kim, Chan Jong
Format: Online
Language:English
Published: The Korean Society of Pediatric Endocrinology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114045/
id pubmed-4114045
recordtype oai_dc
spelling pubmed-41140452014-07-30 Gigantism caused by growth hormone secreting pituitary adenoma Rhee, Noorisaem Jeong, Kumi Yang, Eun Mi Kim, Chan Jong Case Report Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression was noted during an oral glucose tolerance test (OGTT; nadir serum GH, 22.7 ng/mL). Magnetic resonance imaging (MRI) of the brain revealed a 12-mm-sized pituitary adenoma. Transsphenoidal surgery was performed and a pituitary adenoma displaying positive immunohistochemical staining for GH was reported. Pituitary MRI scan was performed 4 months after surgery and showed recurrence/residual tumor. Medical treatment with a long-acting somatostatin analogue for six months was unsuccessful. As a result, secondary surgery was performed. Three months after reoperation, the GH level was 0.2 ng/mL and insulin-like growth factor 1 was 205 ng/mL. Case two involved a 14.9-year-old boy, who was referred to our department for his tall stature. His basal GH level was 9.3 ng/mL, and failure of GH suppression was reported during OGTT (nadir GH, 9.0 ng/mL). Pituitary MRI showed a 6-mm-sized pituitary adenoma. Surgery was done and histopathological examination demonstrated a pituitary adenoma with positive staining for GH. Three months after surgery, the GH level was 0.2 ng/mL and nadir GH during OGTT was less than 0.1 ng/mL. Pituitary MRI scans showed no residual tumor. We present two cases of gigantism caused by a GH-secreting pituitary adenoma with clinical and microscopic findings. The Korean Society of Pediatric Endocrinology 2014-06 2014-06-30 /pmc/articles/PMC4114045/ /pubmed/25077093 http://dx.doi.org/10.6065/apem.2014.19.2.96 Text en © 2014 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rhee, Noorisaem
Jeong, Kumi
Yang, Eun Mi
Kim, Chan Jong
spellingShingle Rhee, Noorisaem
Jeong, Kumi
Yang, Eun Mi
Kim, Chan Jong
Gigantism caused by growth hormone secreting pituitary adenoma
author_facet Rhee, Noorisaem
Jeong, Kumi
Yang, Eun Mi
Kim, Chan Jong
author_sort Rhee, Noorisaem
title Gigantism caused by growth hormone secreting pituitary adenoma
title_short Gigantism caused by growth hormone secreting pituitary adenoma
title_full Gigantism caused by growth hormone secreting pituitary adenoma
title_fullStr Gigantism caused by growth hormone secreting pituitary adenoma
title_full_unstemmed Gigantism caused by growth hormone secreting pituitary adenoma
title_sort gigantism caused by growth hormone secreting pituitary adenoma
description Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression was noted during an oral glucose tolerance test (OGTT; nadir serum GH, 22.7 ng/mL). Magnetic resonance imaging (MRI) of the brain revealed a 12-mm-sized pituitary adenoma. Transsphenoidal surgery was performed and a pituitary adenoma displaying positive immunohistochemical staining for GH was reported. Pituitary MRI scan was performed 4 months after surgery and showed recurrence/residual tumor. Medical treatment with a long-acting somatostatin analogue for six months was unsuccessful. As a result, secondary surgery was performed. Three months after reoperation, the GH level was 0.2 ng/mL and insulin-like growth factor 1 was 205 ng/mL. Case two involved a 14.9-year-old boy, who was referred to our department for his tall stature. His basal GH level was 9.3 ng/mL, and failure of GH suppression was reported during OGTT (nadir GH, 9.0 ng/mL). Pituitary MRI showed a 6-mm-sized pituitary adenoma. Surgery was done and histopathological examination demonstrated a pituitary adenoma with positive staining for GH. Three months after surgery, the GH level was 0.2 ng/mL and nadir GH during OGTT was less than 0.1 ng/mL. Pituitary MRI scans showed no residual tumor. We present two cases of gigantism caused by a GH-secreting pituitary adenoma with clinical and microscopic findings.
publisher The Korean Society of Pediatric Endocrinology
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114045/
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