Regulation of the pentose phosphate pathway in cancer
Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Higher Education Press
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112277/ |
| id |
pubmed-4112277 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-41122772014-07-30 Regulation of the pentose phosphate pathway in cancer Jiang, Peng Du, Wenjing Wu, Mian Review Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway. Higher Education Press 2014-07-12 2014-08 /pmc/articles/PMC4112277/ /pubmed/25015087 http://dx.doi.org/10.1007/s13238-014-0082-8 Text en © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jiang, Peng Du, Wenjing Wu, Mian |
| spellingShingle |
Jiang, Peng Du, Wenjing Wu, Mian Regulation of the pentose phosphate pathway in cancer |
| author_facet |
Jiang, Peng Du, Wenjing Wu, Mian |
| author_sort |
Jiang, Peng |
| title |
Regulation of the pentose phosphate pathway in cancer |
| title_short |
Regulation of the pentose phosphate pathway in cancer |
| title_full |
Regulation of the pentose phosphate pathway in cancer |
| title_fullStr |
Regulation of the pentose phosphate pathway in cancer |
| title_full_unstemmed |
Regulation of the pentose phosphate pathway in cancer |
| title_sort |
regulation of the pentose phosphate pathway in cancer |
| description |
Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway. |
| publisher |
Higher Education Press |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112277/ |
| _version_ |
1613118241547223040 |