Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suff...

Full description

Bibliographic Details
Main Authors: Sales, Katiuchia Uzzun, Friis, Stine, Konkel, Joanne E., Godiksen, Sine, Hatakeyama, Marcia, Hansen, Karina K., Rogatto, Silvia Regina, Szabo, Roman, Vogel, Lotte K., Chen, Wanjun, Gutkind, J. Silvio, Bugge, Thomas H.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112178/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112178/

Similar Items