Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus
Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D–F (3–5), were isolated from the roots of Phyllanthus flexuosus, along with three known lignans. Flexuosoids A (1) and B (2) showed promising antifeedant activity again...
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| Format: | Online |
| Language: | English |
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Springer Berlin Heidelberg
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111870/ |
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pubmed-4111870 |
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oai_dc |
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pubmed-41118702014-07-30 Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus Zhao, Jian-Qiang Wang, Yan-Ming Zhu, Hong-Tao Wang, Dong Li, Sheng-Hong Cheng, Rong-Rong Yang, Chong-Ren Wang, Yi-Fei Xu, Min Zhang, Ying-Jun Original Article Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D–F (3–5), were isolated from the roots of Phyllanthus flexuosus, along with three known lignans. Flexuosoids A (1) and B (2) showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3 μg/cm2, respectively. In addition, both of them and the known lignan glycoside, phyllanthusmin C, displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, with the IC50 values of 11.5, 8.5, and 7.8 μM, respectively. Springer Berlin Heidelberg 2014-07-22 /pmc/articles/PMC4111870/ /pubmed/25089242 http://dx.doi.org/10.1007/s13659-014-0026-2 Text en © The Author(s) 2014 This article is published under license to BioMed Central Ltd. Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhao, Jian-Qiang Wang, Yan-Ming Zhu, Hong-Tao Wang, Dong Li, Sheng-Hong Cheng, Rong-Rong Yang, Chong-Ren Wang, Yi-Fei Xu, Min Zhang, Ying-Jun |
| spellingShingle |
Zhao, Jian-Qiang Wang, Yan-Ming Zhu, Hong-Tao Wang, Dong Li, Sheng-Hong Cheng, Rong-Rong Yang, Chong-Ren Wang, Yi-Fei Xu, Min Zhang, Ying-Jun Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| author_facet |
Zhao, Jian-Qiang Wang, Yan-Ming Zhu, Hong-Tao Wang, Dong Li, Sheng-Hong Cheng, Rong-Rong Yang, Chong-Ren Wang, Yi-Fei Xu, Min Zhang, Ying-Jun |
| author_sort |
Zhao, Jian-Qiang |
| title |
Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| title_short |
Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| title_full |
Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| title_fullStr |
Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| title_full_unstemmed |
Highly Oxygenated Limonoids and Lignans from Phyllanthus flexuosus |
| title_sort |
highly oxygenated limonoids and lignans from phyllanthus flexuosus |
| description |
Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D–F (3–5), were isolated from the roots of Phyllanthus flexuosus, along with three known lignans. Flexuosoids A (1) and B (2) showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3 μg/cm2, respectively. In addition, both of them and the known lignan glycoside, phyllanthusmin C, displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, with the IC50 values of 11.5, 8.5, and 7.8 μM, respectively. |
| publisher |
Springer Berlin Heidelberg |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111870/ |
| _version_ |
1613118140866101248 |