Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat

Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat

There are no reported spontaneous cases of pancreatic ductal adenocarcinoma (PDAC), and there are few reports about chemically-induced PDAC in rats. We encountered a PDAC in a Wistar Hannover GALAS rat that had been subjected to a medium-term multiorgan carcinogenicity bioassay. This article descri...

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Main Authors: Kuroda, Yusuke, Hayashi, Seigo, Hagio, Soichiro, Abe, Masayoshi, Furukawa, Satoshi, Nakae, Dai
Format: Online
Language:English
Published: Japanese Society of Toxicologic Pathology 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110940/
id pubmed-4110940
recordtype oai_dc
spelling pubmed-41109402014-10-28 Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat Kuroda, Yusuke Hayashi, Seigo Hagio, Soichiro Abe, Masayoshi Furukawa, Satoshi Nakae, Dai Case Report There are no reported spontaneous cases of pancreatic ductal adenocarcinoma (PDAC), and there are few reports about chemically-induced PDAC in rats. We encountered a PDAC in a Wistar Hannover GALAS rat that had been subjected to a medium-term multiorgan carcinogenicity bioassay. This article describes the histological and histochemical findings of the tumor. The tumor was located in the pancreatic tissue and had not invaded the liver parenchyma or the mucosal layer of the alimentary tract. The tumor cells were atypical and were mainly arranged in small tubules. In addition, abundant stroma and mucus production were observed in the tumor. In an immunohistochemical examination, the tumor cells were positive for cytokeratin, Sox9 and pancreas duodenum homeobox 1 and negative for amylase 2A and insulin. Therefore, the tumor was diagnosed as a PDAC based on its histological and histochemical findings. We considered that the tumor was caused by the carcinogens administered during the abovementioned bioassay. Japanese Society of Toxicologic Pathology 2013-12-29 2014-07 /pmc/articles/PMC4110940/ /pubmed/25352717 http://dx.doi.org/10.1293/tox.2013-0068 Text en ©2014 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kuroda, Yusuke
Hayashi, Seigo
Hagio, Soichiro
Abe, Masayoshi
Furukawa, Satoshi
Nakae, Dai
spellingShingle Kuroda, Yusuke
Hayashi, Seigo
Hagio, Soichiro
Abe, Masayoshi
Furukawa, Satoshi
Nakae, Dai
Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
author_facet Kuroda, Yusuke
Hayashi, Seigo
Hagio, Soichiro
Abe, Masayoshi
Furukawa, Satoshi
Nakae, Dai
author_sort Kuroda, Yusuke
title Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
title_short Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
title_full Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
title_fullStr Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
title_full_unstemmed Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat
title_sort pancreatic ductal adenocarcinoma in a wistar hannover galas rat
description There are no reported spontaneous cases of pancreatic ductal adenocarcinoma (PDAC), and there are few reports about chemically-induced PDAC in rats. We encountered a PDAC in a Wistar Hannover GALAS rat that had been subjected to a medium-term multiorgan carcinogenicity bioassay. This article describes the histological and histochemical findings of the tumor. The tumor was located in the pancreatic tissue and had not invaded the liver parenchyma or the mucosal layer of the alimentary tract. The tumor cells were atypical and were mainly arranged in small tubules. In addition, abundant stroma and mucus production were observed in the tumor. In an immunohistochemical examination, the tumor cells were positive for cytokeratin, Sox9 and pancreas duodenum homeobox 1 and negative for amylase 2A and insulin. Therefore, the tumor was diagnosed as a PDAC based on its histological and histochemical findings. We considered that the tumor was caused by the carcinogens administered during the abovementioned bioassay.
publisher Japanese Society of Toxicologic Pathology
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110940/
_version_ 1613117909666627584

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