Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models

Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models

Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ...

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Main Authors: Queiroz, João Carlos C., Antoniolli, Ângelo R., Quintans-Júnior, Lucindo J., Brito, Renan G., Barreto, Rosana S. S., Costa, Emmanoel V., da Silva, Thanany B., Prata, Ana Paula Nascimento, de Lucca, Waldecy, Almeida, Jackson R. G. S., Lima, Julianeli T., Quintans, Jullyana S. S.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/
id pubmed-4109226
recordtype oai_dc
spelling pubmed-41092262014-08-05 Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models Queiroz, João Carlos C. Antoniolli, Ângelo R. Quintans-Júnior, Lucindo J. Brito, Renan G. Barreto, Rosana S. S. Costa, Emmanoel V. da Silva, Thanany B. Prata, Ana Paula Nascimento de Lucca, Waldecy Almeida, Jackson R. G. S. Lima, Julianeli T. Quintans, Jullyana S. S. Research Article Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. Hindawi Publishing Corporation 2014 2014-07-03 /pmc/articles/PMC4109226/ /pubmed/25097889 http://dx.doi.org/10.1155/2014/816450 Text en Copyright © 2014 João Carlos C. Queiroz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
spellingShingle Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
author_facet Queiroz, João Carlos C.
Antoniolli, Ângelo R.
Quintans-Júnior, Lucindo J.
Brito, Renan G.
Barreto, Rosana S. S.
Costa, Emmanoel V.
da Silva, Thanany B.
Prata, Ana Paula Nascimento
de Lucca, Waldecy
Almeida, Jackson R. G. S.
Lima, Julianeli T.
Quintans, Jullyana S. S.
author_sort Queiroz, João Carlos C.
title Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_short Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_full Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_fullStr Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_full_unstemmed Evaluation of the Anti-Inflammatory and Antinociceptive Effects of the Essential Oil from Leaves of Xylopia laevigata in Experimental Models
title_sort evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of xylopia laevigata in experimental models
description Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of γ-muurolene (17.78%), δ-cadinene (12.23%), bicyclogermacrene (7.77%), and α-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (P < 0.05 or P < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (P < 0.01 or P < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.
publisher Hindawi Publishing Corporation
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109226/
_version_ 1613117421245169664

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