A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects

The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE) interactions. Yet, the detec...

Full description

Bibliographic Details
Main Authors: Marigorta, Urko M., Gibson, Greg
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104702/