Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, als...

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Bibliographic Details
Main Authors: Hunter, Roger W., Foretz, Marc, Bultot, Laurent, Fullerton, Morgan D., Deak, Maria, Ross, Fiona A., Hawley, Simon A., Shpiro, Natalia, Viollet, Benoit, Barron, Denis, Kemp, Bruce E., Steinberg, Gregory R., Hardie, D. Grahame, Sakamoto, Kei
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104029/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104029/

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