Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy

Schistosome parasites still represent a serious public health concern and a major economic problem in developing countries. Pathology of schistosomiasis is mainly due to massive egg production by these parasites and to inflammatory responses raised against the eggs which are trapped in host tissues....

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Main Authors:	Morel, Marion, Vanderstraete, Mathieu, Hahnel, Steffen, Grevelding, Christoph G., Dissous, Colette
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102852/

id	pubmed-4102852
recordtype	oai_dc
spelling	pubmed-41028522014-08-06 Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy Morel, Marion Vanderstraete, Mathieu Hahnel, Steffen Grevelding, Christoph G. Dissous, Colette Genetics Schistosome parasites still represent a serious public health concern and a major economic problem in developing countries. Pathology of schistosomiasis is mainly due to massive egg production by these parasites and to inflammatory responses raised against the eggs which are trapped in host tissues. Tyrosine kinases (TKs) are key molecules that control cell differentiation and proliferation and they already represent important targets in cancer therapy. During recent years, it has been shown that receptor tyrosine kinases (RTK) signaling was active in reproductive organs and that it could regulate sexual maturation of schistosomes and egg production. This opens interesting perspectives for the control of transmission and pathogenesis of schistosomiasis based on new therapies targeting schistosome RTKs. This review relates the numerous data showing the major roles of kinase signaling in schistosome reproduction. It describes the conserved and particular features of schistosome RTKs, their implication in gametogenesis and reproduction processes and summarizes recent works indicating that RTKs and their signaling partners are interesting chemotherapeutical targets in new programs of control. Frontiers Media S.A. 2014-07-18 /pmc/articles/PMC4102852/ /pubmed/25101117 http://dx.doi.org/10.3389/fgene.2014.00238 Text en Copyright © 2014 Morel, Vanderstraete, Hahnel, Grevelding and Dissous. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Morel, Marion Vanderstraete, Mathieu Hahnel, Steffen Grevelding, Christoph G. Dissous, Colette
spellingShingle	Morel, Marion Vanderstraete, Mathieu Hahnel, Steffen Grevelding, Christoph G. Dissous, Colette Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
author_facet	Morel, Marion Vanderstraete, Mathieu Hahnel, Steffen Grevelding, Christoph G. Dissous, Colette
author_sort	Morel, Marion
title	Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
title_short	Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
title_full	Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
title_fullStr	Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
title_full_unstemmed	Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
title_sort	receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
description	Schistosome parasites still represent a serious public health concern and a major economic problem in developing countries. Pathology of schistosomiasis is mainly due to massive egg production by these parasites and to inflammatory responses raised against the eggs which are trapped in host tissues. Tyrosine kinases (TKs) are key molecules that control cell differentiation and proliferation and they already represent important targets in cancer therapy. During recent years, it has been shown that receptor tyrosine kinases (RTK) signaling was active in reproductive organs and that it could regulate sexual maturation of schistosomes and egg production. This opens interesting perspectives for the control of transmission and pathogenesis of schistosomiasis based on new therapies targeting schistosome RTKs. This review relates the numerous data showing the major roles of kinase signaling in schistosome reproduction. It describes the conserved and particular features of schistosome RTKs, their implication in gametogenesis and reproduction processes and summarizes recent works indicating that RTKs and their signaling partners are interesting chemotherapeutical targets in new programs of control.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102852/
_version_	1613115497104015360

Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy

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