T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through direct modulation of PD-1....

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Bibliographic Details
Main Authors: Buggert, Marcus, Tauriainen, Johanna, Yamamoto, Takuya, Frederiksen, Juliet, Ivarsson, Martin A., Michaëlsson, Jakob, Lund, Ole, Hejdeman, Bo, Jansson, Marianne, Sönnerborg, Anders, Koup, Richard A., Betts, Michael R., Karlsson, Annika C.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102564/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102564/

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