Electrical Stimulation Therapy for Gastroesophageal Reflux Disease

Electrical Stimulation Therapy for Gastroesophageal Reflux Disease

Electrical stimulation therapy (EST) of the lower esophageal sphincter is a relatively new technique for the treatment of gastroesophageal reflux disease (GERD) that may address the need of GERD patients, unsatisfied with acid suppressive medication and concerned with the potential risks of surgical...

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Main Authors: Rinsma, Nicolaas F, Bouvy, Nicole D, Masclee, Ad A M, Conchillo, José M
Format: Online
Language:English
Published: Korean Society of Neurogastroenterology and Motility 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102155/
id pubmed-4102155
recordtype oai_dc
spelling pubmed-41021552014-07-18 Electrical Stimulation Therapy for Gastroesophageal Reflux Disease Rinsma, Nicolaas F Bouvy, Nicole D Masclee, Ad A M Conchillo, José M Review Electrical stimulation therapy (EST) of the lower esophageal sphincter is a relatively new technique for the treatment of gastroesophageal reflux disease (GERD) that may address the need of GERD patients, unsatisfied with acid suppressive medication and concerned with the potential risks of surgical fundoplication. In this paper we review available data about EST for GERD, including the development of the technique, implant procedure, safety and results from open-label trials. Two short-term temporary stimulation and long-term open-label human trials each were initiated to investigate the safety and efficacy of EST for the treatment of GERD and currently up to 2 years follow-up results are available. The results of EST are promising as the open-label studies have shown that EST is a safe technique with a significant improvement in both subjective outcomes of symptoms and objective outcomes of esophageal acid exposure in patients with GERD. However, long-term data from larger number of patients and a sham-controlled trial are required before EST can be conclusively advised as a viable treatment option for GERD patients. Korean Society of Neurogastroenterology and Motility 2014-07 /pmc/articles/PMC4102155/ /pubmed/24847842 http://dx.doi.org/10.5056/jnm13137 Text en ©2014 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Rinsma, Nicolaas F
Bouvy, Nicole D
Masclee, Ad A M
Conchillo, José M
spellingShingle Rinsma, Nicolaas F
Bouvy, Nicole D
Masclee, Ad A M
Conchillo, José M
Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
author_facet Rinsma, Nicolaas F
Bouvy, Nicole D
Masclee, Ad A M
Conchillo, José M
author_sort Rinsma, Nicolaas F
title Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
title_short Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
title_full Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
title_fullStr Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
title_full_unstemmed Electrical Stimulation Therapy for Gastroesophageal Reflux Disease
title_sort electrical stimulation therapy for gastroesophageal reflux disease
description Electrical stimulation therapy (EST) of the lower esophageal sphincter is a relatively new technique for the treatment of gastroesophageal reflux disease (GERD) that may address the need of GERD patients, unsatisfied with acid suppressive medication and concerned with the potential risks of surgical fundoplication. In this paper we review available data about EST for GERD, including the development of the technique, implant procedure, safety and results from open-label trials. Two short-term temporary stimulation and long-term open-label human trials each were initiated to investigate the safety and efficacy of EST for the treatment of GERD and currently up to 2 years follow-up results are available. The results of EST are promising as the open-label studies have shown that EST is a safe technique with a significant improvement in both subjective outcomes of symptoms and objective outcomes of esophageal acid exposure in patients with GERD. However, long-term data from larger number of patients and a sham-controlled trial are required before EST can be conclusively advised as a viable treatment option for GERD patients.
publisher Korean Society of Neurogastroenterology and Motility
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102155/
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