The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects...

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Main Authors:	Kim, Sunyoung, Won, Chang Won, Kim, Byung Sung, Choi, Hyun Rim, Moon, Min Young
Format:	Online
Language:	English
Published:	The Korean Academy of Medical Sciences 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101790/

id	pubmed-4101790
recordtype	oai_dc
spelling	pubmed-41017902014-07-18 The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People Kim, Sunyoung Won, Chang Won Kim, Byung Sung Choi, Hyun Rim Moon, Min Young Original Article The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht2 was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker for osteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture. The Korean Academy of Medical Sciences 2014-07 2014-07-11 /pmc/articles/PMC4101790/ /pubmed/25045234 http://dx.doi.org/10.3346/jkms.2014.29.7.995 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Sunyoung Won, Chang Won Kim, Byung Sung Choi, Hyun Rim Moon, Min Young
spellingShingle	Kim, Sunyoung Won, Chang Won Kim, Byung Sung Choi, Hyun Rim Moon, Min Young The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
author_facet	Kim, Sunyoung Won, Chang Won Kim, Byung Sung Choi, Hyun Rim Moon, Min Young
author_sort	Kim, Sunyoung
title	The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
title_short	The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
title_full	The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
title_fullStr	The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
title_full_unstemmed	The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People
title_sort	association between the low muscle mass and osteoporosis in elderly korean people
description	The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht2 was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker for osteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture.
publisher	The Korean Academy of Medical Sciences
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101790/
_version_	1613115125202419712

The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People

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