DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells

Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in...

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Bibliographic Details
Main Authors: Laos, Maarja, Anttonen, Tommi, Kirjavainen, Anna, Hällström, Taija af, Laiho, Marikki, Pirvola, Ulla
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100811/