Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases
Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibrobl...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099112/ |
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pubmed-4099112 |
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pubmed-40991122014-07-22 Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases Buenrostro, Denise Park, Serk In Sterling, Julie A. Review Article Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment. Hindawi Publishing Corporation 2014 2014-06-26 /pmc/articles/PMC4099112/ /pubmed/25054153 http://dx.doi.org/10.1155/2014/875305 Text en Copyright © 2014 Denise Buenrostro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Buenrostro, Denise Park, Serk In Sterling, Julie A. |
| spellingShingle |
Buenrostro, Denise Park, Serk In Sterling, Julie A. Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| author_facet |
Buenrostro, Denise Park, Serk In Sterling, Julie A. |
| author_sort |
Buenrostro, Denise |
| title |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| title_short |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| title_full |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| title_fullStr |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| title_full_unstemmed |
Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases |
| title_sort |
dissecting the role of bone marrow stromal cells on bone metastases |
| description |
Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow. These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells. Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment. Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells. While many groups focus on studying these interactions, much remains unknown. A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases. This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099112/ |
| _version_ |
1613114043942305792 |