High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms☆
•Glutamate-gated chloride channels (GluCl) are targets for avermectin/milbemycin (A/M) anthelmintics.•Little is known regarding the mechanism of A/M anthelmintics to reduce microfilaria production and release in filarial worms.•We show that two GluCl subunits gene are expressed in developing embryos...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095040/ |