A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow

A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by overproduction of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked t...

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Main Authors: Byun, Young Jae, Park, Byeong-Bae, Lee, Eun Sung, Choi, Kyung Soo, Lee, Dae Sung
Format: Online
Language:English
Published: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090334/
id pubmed-4090334
recordtype oai_dc
spelling pubmed-40903342014-07-14 A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow Byun, Young Jae Park, Byeong-Bae Lee, Eun Sung Choi, Kyung Soo Lee, Dae Sung Case Report Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by overproduction of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked thrombocytosis in peripheral blood. However, Philadelphia chromosome-positivity or bcr/abl rearrangement with isolated thrombocytosis should be diagnosed as CML, not ET, according to World Health Organization diagnostic criteria. Therefore, CML should not be excluded before confirming the presence of the Philadelphia chromosome or bcr/abl rearrangement in cases of isolated thrombocytosis in peripheral blood. We report a case of CML with clinical features of ET in a patient successfully treated with imatinib. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2014-06 2014-06-25 /pmc/articles/PMC4090334/ /pubmed/25025015 http://dx.doi.org/10.5045/br.2014.49.2.127 Text en © 2014 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Byun, Young Jae
Park, Byeong-Bae
Lee, Eun Sung
Choi, Kyung Soo
Lee, Dae Sung
spellingShingle Byun, Young Jae
Park, Byeong-Bae
Lee, Eun Sung
Choi, Kyung Soo
Lee, Dae Sung
A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
author_facet Byun, Young Jae
Park, Byeong-Bae
Lee, Eun Sung
Choi, Kyung Soo
Lee, Dae Sung
author_sort Byun, Young Jae
title A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
title_short A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
title_full A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
title_fullStr A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
title_full_unstemmed A case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
title_sort case of chronic myeloid leukemia with features of essential thrombocythemia in peripheral blood and bone marrow
description Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by overproduction of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked thrombocytosis in peripheral blood. However, Philadelphia chromosome-positivity or bcr/abl rearrangement with isolated thrombocytosis should be diagnosed as CML, not ET, according to World Health Organization diagnostic criteria. Therefore, CML should not be excluded before confirming the presence of the Philadelphia chromosome or bcr/abl rearrangement in cases of isolated thrombocytosis in peripheral blood. We report a case of CML with clinical features of ET in a patient successfully treated with imatinib.
publisher Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090334/
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