Future directions for the management of pain in osteoarthritis
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA in the long term. Current treatments are larg...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089899/ |
| id |
pubmed-4089899 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-40898992014-07-09 Future directions for the management of pain in osteoarthritis Sofat, Nidhi Kuttapitiya, Anasuya Article Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA in the long term. Current treatments are largely based on the modulation of pain, including NSAIDs, opiates and, more recently, centrally acting pharmacotherapies to avert pain. This review will focus on the rationale for new avenues in pain modulation, including inhibition with anti-NGF antibodies and centrally acting analgesics. The authors also consider the potential for structure modification in cartilage/bone using growth factors and stem cell therapies. The possible mismatch between structural change and pain perception will also be discussed, introducing recent techniques that may assist in improved patient phenotyping of pain subsets in OA. Such developments could help further stratify subgroups and treatments for people with OA in future. 2014-04 /pmc/articles/PMC4089899/ /pubmed/25018771 Text en Open access This article is distributed under the terms of the Creative Commons Attribution License 3.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sofat, Nidhi Kuttapitiya, Anasuya |
| spellingShingle |
Sofat, Nidhi Kuttapitiya, Anasuya Future directions for the management of pain in osteoarthritis |
| author_facet |
Sofat, Nidhi Kuttapitiya, Anasuya |
| author_sort |
Sofat, Nidhi |
| title |
Future directions for the management of pain in osteoarthritis |
| title_short |
Future directions for the management of pain in osteoarthritis |
| title_full |
Future directions for the management of pain in osteoarthritis |
| title_fullStr |
Future directions for the management of pain in osteoarthritis |
| title_full_unstemmed |
Future directions for the management of pain in osteoarthritis |
| title_sort |
future directions for the management of pain in osteoarthritis |
| description |
Osteoarthritis (OA) is the predominant form of arthritis worldwide, resulting in a high degree of functional impairment and reduced quality of life owing to chronic pain. To date, there are no treatments that are known to modify disease progression of OA in the long term. Current treatments are largely based on the modulation of pain, including NSAIDs, opiates and, more recently, centrally acting pharmacotherapies to avert pain. This review will focus on the rationale for new avenues in pain modulation, including inhibition with anti-NGF antibodies and centrally acting analgesics. The authors also consider the potential for structure modification in cartilage/bone using growth factors and stem cell therapies. The possible mismatch between structural change and pain perception will also be discussed, introducing recent techniques that may assist in improved patient phenotyping of pain subsets in OA. Such developments could help further stratify subgroups and treatments for people with OA in future. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089899/ |
| _version_ |
1613110815533039616 |