Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics
Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target ‘foreign’ sequences present in the complementarity determining regions (CDRs). Humanization of the mAb...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Informa Healthcare
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086238/ |