Detecting Signals in Pharmacogenomic Genome-Wide Association Studies

In one common pharmacogenomic scenario, outcome measures are compared for treated and untreated subjects across genotype defined subgroups. The key question is whether treatment benefit (or harm) is particularly strong in certain subgroups, and therefore statistical analysis focuses on the interacti...

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Bibliographic Details
Main Authors: Wakefield, Jon, Skrivankova, Veronika, Hsu, Fang-Chi, Sale, Michele, Heagerty, Patrick
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085158/