On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield

In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decohe...

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Main Authors:	Raković, Dejan, Dugić, Miroljub, Jeknić-Dugić, Jasmina, Plavšić, Milenko, Jaćimovski, Stevo, Šetrajčić, Jovan
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084588/

id	pubmed-4084588
recordtype	oai_dc
spelling	pubmed-40845882014-07-15 On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield Raković, Dejan Dugić, Miroljub Jeknić-Dugić, Jasmina Plavšić, Milenko Jaćimovski, Stevo Šetrajčić, Jovan Research Article In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by quantum-chemical and quantum decoherence laws. On the other hand, within an open biological cell, a system of all identical (noninteracting and dynamically noncoupled) biomolecular proteins might be considered as corresponding spatial quantum ensemble of these identical biomolecular processors, providing spatially distributed quantum solution to a single corresponding biomolecular chain folding, whose density of conformational states might be represented as Hopfield-like quantum-holographic associative neural network too (providing an equivalent global quantum-informational alternative to standard molecular-biology local biochemical approach in biomolecules and cells and higher hierarchical levels of organism, as well). Hindawi Publishing Corporation 2014 2014-06-16 /pmc/articles/PMC4084588/ /pubmed/25028662 http://dx.doi.org/10.1155/2014/580491 Text en Copyright © 2014 Dejan Raković et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Raković, Dejan Dugić, Miroljub Jeknić-Dugić, Jasmina Plavšić, Milenko Jaćimovski, Stevo Šetrajčić, Jovan
spellingShingle	Raković, Dejan Dugić, Miroljub Jeknić-Dugić, Jasmina Plavšić, Milenko Jaćimovski, Stevo Šetrajčić, Jovan On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
author_facet	Raković, Dejan Dugić, Miroljub Jeknić-Dugić, Jasmina Plavšić, Milenko Jaćimovski, Stevo Šetrajčić, Jovan
author_sort	Raković, Dejan
title	On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
title_short	On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
title_full	On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
title_fullStr	On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
title_full_unstemmed	On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield
title_sort	on macroscopic quantum phenomena in biomolecules and cells: from levinthal to hopfield
description	In the context of the macroscopic quantum phenomena of the second kind, we hereby seek for a solution-in-principle of the long standing problem of the polymer folding, which was considered by Levinthal as (semi)classically intractable. To illuminate it, we applied quantum-chemical and quantum decoherence approaches to conformational transitions. Our analyses imply the existence of novel macroscopic quantum biomolecular phenomena, with biomolecular chain folding in an open environment considered as a subtle interplay between energy and conformation eigenstates of this biomolecule, governed by quantum-chemical and quantum decoherence laws. On the other hand, within an open biological cell, a system of all identical (noninteracting and dynamically noncoupled) biomolecular proteins might be considered as corresponding spatial quantum ensemble of these identical biomolecular processors, providing spatially distributed quantum solution to a single corresponding biomolecular chain folding, whose density of conformational states might be represented as Hopfield-like quantum-holographic associative neural network too (providing an equivalent global quantum-informational alternative to standard molecular-biology local biochemical approach in biomolecules and cells and higher hierarchical levels of organism, as well).
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084588/
_version_	1613109211581906944

On Macroscopic Quantum Phenomena in Biomolecules and Cells: From Levinthal to Hopfield

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