A mutation in POLE predisposing to a multi-tumour phenotype
Somatic mutations in the POLE gene encoding the catalytic subunit of DNA polymerase ɛ have been found in sporadic colorectal cancers (CRCs) and are most likely of importance in tumour development and/or progression. Recently, families with dominantly inherited colorectal adenomas and colorectal canc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
D.A. Spandidos
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079162/ |