Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect

Photodynamic therapy using hematoporphyrin and its derivatives is clinically useful for cancer treatments. It has been reported that cancer cells incorporate hematoporphyrin and its derivatives via heme carrier protein 1, which is a proton-coupled folate transporter. However, the mechanism of this p...

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Bibliographic Details
Main Authors: Ito, Hiromu, Matsui, Hirofumi, Tamura, Masato, Majima, Hideyuki J., Indo, Hiroko P., Hyodo, Ichinosuke
Format: Online
Language:English
Published: the Society for Free Radical Research Japan 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078070/