Endoplasmic reticulum stress response in yeast and humans

Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the UPR (unfolded protein response), is an intracellular signal transduction pathway that monitors ER (endoplasmic reticulum) homoeostasis. Its act...

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Main Authors:	Wu, Haoxi, Ng, Benjamin S. H., Thibault, Guillaume
Format:	Online
Language:	English
Published:	Portland Press Ltd. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076835/

id	pubmed-4076835
recordtype	oai_dc
spelling	pubmed-40768352014-07-11 Endoplasmic reticulum stress response in yeast and humans Wu, Haoxi Ng, Benjamin S. H. Thibault, Guillaume Review Article Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the UPR (unfolded protein response), is an intracellular signal transduction pathway that monitors ER (endoplasmic reticulum) homoeostasis. Its activation is required to alleviate the effects of ER stress and is highly conserved from yeast to human. Although metazoans have three UPR outputs, yeast cells rely exclusively on the Ire1 (inositol-requiring enzyme-1) pathway, which is conserved in all Eukaryotes. In general, the UPR program activates hundreds of genes to alleviate ER stress but it can lead to apoptosis if the system fails to restore homoeostasis. In this review, we summarize the major advances in understanding the response to ER stress in Sc (Saccharomyces cerevisiae), Sp (Schizosaccharomyces pombe) and humans. The contribution of solved protein structures to a better understanding of the UPR pathway is discussed. Finally, we cover the interplay of ER stress in the development of diseases. Portland Press Ltd. 2014-07-01 /pmc/articles/PMC4076835/ /pubmed/24909749 http://dx.doi.org/10.1042/BSR20140058 Text en © 2014 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wu, Haoxi Ng, Benjamin S. H. Thibault, Guillaume
spellingShingle	Wu, Haoxi Ng, Benjamin S. H. Thibault, Guillaume Endoplasmic reticulum stress response in yeast and humans
author_facet	Wu, Haoxi Ng, Benjamin S. H. Thibault, Guillaume
author_sort	Wu, Haoxi
title	Endoplasmic reticulum stress response in yeast and humans
title_short	Endoplasmic reticulum stress response in yeast and humans
title_full	Endoplasmic reticulum stress response in yeast and humans
title_fullStr	Endoplasmic reticulum stress response in yeast and humans
title_full_unstemmed	Endoplasmic reticulum stress response in yeast and humans
title_sort	endoplasmic reticulum stress response in yeast and humans
description	Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the UPR (unfolded protein response), is an intracellular signal transduction pathway that monitors ER (endoplasmic reticulum) homoeostasis. Its activation is required to alleviate the effects of ER stress and is highly conserved from yeast to human. Although metazoans have three UPR outputs, yeast cells rely exclusively on the Ire1 (inositol-requiring enzyme-1) pathway, which is conserved in all Eukaryotes. In general, the UPR program activates hundreds of genes to alleviate ER stress but it can lead to apoptosis if the system fails to restore homoeostasis. In this review, we summarize the major advances in understanding the response to ER stress in Sc (Saccharomyces cerevisiae), Sp (Schizosaccharomyces pombe) and humans. The contribution of solved protein structures to a better understanding of the UPR pathway is discussed. Finally, we cover the interplay of ER stress in the development of diseases.
publisher	Portland Press Ltd.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076835/
_version_	1612108229419991040

Endoplasmic reticulum stress response in yeast and humans

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