An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)...

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Bibliographic Details
Main Authors: Peng, Nan, Meng, Ning, Wang, ShengQing, Zhao, Fei, Zhao, Jing, Su, Le, Zhang, ShangLi, Zhang, Yun, Zhao, BaoXiang, Miao, JunYing
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076681/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076681/

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