Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

IFN-γ directly triggers degranulation and death of Paneth cells, which do not respond to microbial stimulation in primary culture.

Bibliographic Details
Main Authors: Farin, Henner F., Karthaus, Wouter R., Kujala, Pekka, Rakhshandehroo, Maryam, Schwank, Gerald, Vries, Robert G.J., Kalkhoven, Eric, Nieuwenhuis, Edward E.S., Clevers, Hans
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076587/