Destabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation

Destabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation

HuR promotes myogenesis by stabilizing the MyoD, Myogenin and p21 mRNAs during the fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA destabilizing activity, promotes the early steps of myogenesis by reducing the expression of the cell cycle promoter nucleophosmin (NPM)...

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Bibliographic Details
Main Authors: Cammas, Anne, Sanchez, Brenda Janice, Lian, Xian Jin, Dormoy-Raclet, Virginie, van der Giessen, Kate, de Silanes, Isabel López, Ma, Jennifer, Wilusz, Carol, Richardson, John, Gorospe, Myriam, Millevoi, Stefania, Giovarelli, Matteo, Gherzi, Roberto, Di Marco, Sergio, Gallouzi, Imed-Eddine
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074165/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074165/

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