Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients

Background. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipod...

Full description

Bibliographic Details
Main Authors:	Gundurao Sreekantamurthy, Gurudath, Singh, N Biplab, Singh, Th Bhimo, Singh, Th Suraj, Singh, Karam Romeo
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070330/

id	pubmed-4070330
recordtype	oai_dc
spelling	pubmed-40703302014-07-10 Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients Gundurao Sreekantamurthy, Gurudath Singh, N Biplab Singh, Th Bhimo Singh, Th Suraj Singh, Karam Romeo Clinical Study Background. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipodystrophy. Study Design. One hundred and one HIV male patients were categorised into ART naïve (n = 22), zidovudine (n = 22), stavudine (n = 18), tenofovir (n = 15), and PIs (n = 24) based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results. Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3%) and PIs (20 patients, 83.3%) based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%). The waist-hip ratio was significantly higher in PIs (P = 0.01) based HAART. There was no significant difference among different study populations in terms of BMI (P = 0.917), body water (P = 0.318), body fat (P = 0.172), bone mass (P = 0.200), and muscle mass (P = 0.070). Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL) was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion. Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face. Hindawi Publishing Corporation 2014 2014-06-10 /pmc/articles/PMC4070330/ /pubmed/25013726 http://dx.doi.org/10.1155/2014/498497 Text en Copyright © 2014 Gurudath Gundurao Sreekantamurthy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gundurao Sreekantamurthy, Gurudath Singh, N Biplab Singh, Th Bhimo Singh, Th Suraj Singh, Karam Romeo
spellingShingle	Gundurao Sreekantamurthy, Gurudath Singh, N Biplab Singh, Th Bhimo Singh, Th Suraj Singh, Karam Romeo Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
author_facet	Gundurao Sreekantamurthy, Gurudath Singh, N Biplab Singh, Th Bhimo Singh, Th Suraj Singh, Karam Romeo
author_sort	Gundurao Sreekantamurthy, Gurudath
title	Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
title_short	Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
title_full	Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
title_fullStr	Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
title_full_unstemmed	Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
title_sort	study of body composition and metabolic parameters in hiv-1 male patients
description	Background. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipodystrophy. Study Design. One hundred and one HIV male patients were categorised into ART naïve (n = 22), zidovudine (n = 22), stavudine (n = 18), tenofovir (n = 15), and PIs (n = 24) based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results. Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3%) and PIs (20 patients, 83.3%) based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%). The waist-hip ratio was significantly higher in PIs (P = 0.01) based HAART. There was no significant difference among different study populations in terms of BMI (P = 0.917), body water (P = 0.318), body fat (P = 0.172), bone mass (P = 0.200), and muscle mass (P = 0.070). Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL) was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion. Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070330/
_version_	1612105944132485120

Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients

Similar Items