Structure guided homology model based design and engineering of mouse antibodies for humanization
No universal strategy exists for humanizing mouse antibodies, and most approaches are based on primary sequence alignment and grafting. Although this strategy theoretically decreases the immunogenicity of mouse antibodies, it neither addresses conformational changes nor steric clashes that arise d...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Biomedical Informatics
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070046/ |