The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host–parasite interaction

Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes...

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Main Authors: Jackson, Andrew P., Otto, Thomas D., Darby, Alistair, Ramaprasad, Abhinay, Xia, Dong, Echaide, Ignacio Eduardo, Farber, Marisa, Gahlot, Sunayna, Gamble, John, Gupta, Dinesh, Gupta, Yask, Jackson, Louise, Malandrin, Laurence, Malas, Tareq B., Moussa, Ehab, Nair, Mridul, Reid, Adam J., Sanders, Mandy, Sharma, Jyotsna, Tracey, Alan, Quail, Mike A., Weir, William, Wastling, Jonathan M., Hall, Neil, Willadsen, Peter, Lingelbach, Klaus, Shiels, Brian, Tait, Andy, Berriman, Matt, Allred, David R., Pain, Arnab
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066756/

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