Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics

Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment re...

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Main Authors:	Kim, Jong-Heon, Yun, Sung-Ho, Jang, Kwang-Ho, Park, Jaechan, Han, Hyung Soo, Rhee, Dongick, Suk, Kyoungho
Format:	Online
Language:	English
Published:	The Korean Society for Brain and Neural Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065824/

id	pubmed-4065824
recordtype	oai_dc
spelling	pubmed-40658242014-06-24 Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics Kim, Jong-Heon Yun, Sung-Ho Jang, Kwang-Ho Park, Jaechan Han, Hyung Soo Rhee, Dongick Suk, Kyoungho Review Article Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and associated risks. Here, we review the protective effects-and the cellular mechanisms that underlie them-of delayed and prolonged local hypothermia in rodent and canine brain injury models. The data show that the protective effects of therapeutic hypothermia, which mainly result from the modulation of inflammatory glial dynamics, are limited. We argue that decompressive craniectomy can be used to overcome the limitations of local brain hypothermia without causing histological abnormalities or other detrimental effects to the cooled area. Therefore, delayed and prolonged local brain hypothermia at the site of craniectomy is a promising intervention that may prove effective in the clinical setting. The Korean Society for Brain and Neural Science 2014-06 2014-06-13 /pmc/articles/PMC4065824/ /pubmed/24963275 http://dx.doi.org/10.5607/en.2014.23.2.115 Text en Copyright © Experimental Neurobiology 2014. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Jong-Heon Yun, Sung-Ho Jang, Kwang-Ho Park, Jaechan Han, Hyung Soo Rhee, Dongick Suk, Kyoungho
spellingShingle	Kim, Jong-Heon Yun, Sung-Ho Jang, Kwang-Ho Park, Jaechan Han, Hyung Soo Rhee, Dongick Suk, Kyoungho Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
author_facet	Kim, Jong-Heon Yun, Sung-Ho Jang, Kwang-Ho Park, Jaechan Han, Hyung Soo Rhee, Dongick Suk, Kyoungho
author_sort	Kim, Jong-Heon
title	Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_short	Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_full	Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_fullStr	Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_full_unstemmed	Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics
title_sort	delayed and prolonged local brain hypothermia combined with decompressive craniectomy: a novel therapeutic strategy that modulates glial dynamics
description	Hypothermia is considered a useful intervention for limiting pathophysiological changes after brain injury. Local hypothermia is a relatively safe and convenient intervention that circumvents many of the complications associated with systemic hypothermia. However, successful hypothermia treatment requires careful consideration of several factors including its practicality, feasibility, and associated risks. Here, we review the protective effects-and the cellular mechanisms that underlie them-of delayed and prolonged local hypothermia in rodent and canine brain injury models. The data show that the protective effects of therapeutic hypothermia, which mainly result from the modulation of inflammatory glial dynamics, are limited. We argue that decompressive craniectomy can be used to overcome the limitations of local brain hypothermia without causing histological abnormalities or other detrimental effects to the cooled area. Therefore, delayed and prolonged local brain hypothermia at the site of craniectomy is a promising intervention that may prove effective in the clinical setting.
publisher	The Korean Society for Brain and Neural Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065824/
_version_	1612104567609098240

Delayed and Prolonged Local Brain Hypothermia Combined with Decompressive Craniectomy: A Novel Therapeutic Strategy That Modulates Glial Dynamics

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