Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives
With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conv...
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| Format: | Online |
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065701/ |
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pubmed-4065701 |
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pubmed-40657012014-07-03 Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives Sahoo, Ranjan Ku. Biswas, Nikhil Guha, Arijit Sahoo, Nityananda Kuotsu, Ketousetuo Review Article With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs. Hindawi Publishing Corporation 2014 2014-06-03 /pmc/articles/PMC4065701/ /pubmed/24995280 http://dx.doi.org/10.1155/2014/263604 Text en Copyright © 2014 Ranjan Ku. Sahoo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sahoo, Ranjan Ku. Biswas, Nikhil Guha, Arijit Sahoo, Nityananda Kuotsu, Ketousetuo |
| spellingShingle |
Sahoo, Ranjan Ku. Biswas, Nikhil Guha, Arijit Sahoo, Nityananda Kuotsu, Ketousetuo Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| author_facet |
Sahoo, Ranjan Ku. Biswas, Nikhil Guha, Arijit Sahoo, Nityananda Kuotsu, Ketousetuo |
| author_sort |
Sahoo, Ranjan Ku. |
| title |
Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| title_short |
Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| title_full |
Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| title_fullStr |
Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| title_full_unstemmed |
Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives |
| title_sort |
nonionic surfactant vesicles in ocular delivery: innovative approaches and perspectives |
| description |
With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065701/ |
| _version_ |
1612104521980313600 |