Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus

Auditory verbal hallucinations (AVH) are a common phenomenon, occurring in the “healthy” population as well as in several mental illnesses, most notably schizophrenia. Current thinking supports a spectrum conceptualisation of AVH: several neurocognitive hypotheses of AVH have been proposed, includin...

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Main Authors:	Tracy, Derek K., Shergill, Sukhwinder S.
Format:	Online
Language:	English
Published:	MDPI 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061847/

id	pubmed-4061847
recordtype	oai_dc
spelling	pubmed-40618472014-06-19 Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus Tracy, Derek K. Shergill, Sukhwinder S. Review Auditory verbal hallucinations (AVH) are a common phenomenon, occurring in the “healthy” population as well as in several mental illnesses, most notably schizophrenia. Current thinking supports a spectrum conceptualisation of AVH: several neurocognitive hypotheses of AVH have been proposed, including the “feed-forward” model of failure to provide appropriate information to somatosensory cortices so that stimuli appear unbidden, and an “aberrant memory model” implicating deficient memory processes. Neuroimaging and connectivity studies are in broad agreement with these with a general dysconnectivity between frontotemporal regions involved in language, memory and salience properties. Disappointingly many AVH remain resistant to standard treatments and persist for many years. There is a need to develop novel therapies to augment existing pharmacological and psychological therapies: transcranial magnetic stimulation has emerged as a potential treatment, though more recent clinical data has been less encouraging. Our understanding of AVH remains incomplete though much progress has been made in recent years. We herein provide a broad overview and review of this. MDPI 2013-04-26 /pmc/articles/PMC4061847/ /pubmed/24961419 http://dx.doi.org/10.3390/brainsci3020642 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tracy, Derek K. Shergill, Sukhwinder S.
spellingShingle	Tracy, Derek K. Shergill, Sukhwinder S. Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
author_facet	Tracy, Derek K. Shergill, Sukhwinder S.
author_sort	Tracy, Derek K.
title	Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
title_short	Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
title_full	Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
title_fullStr	Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
title_full_unstemmed	Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus
title_sort	mechanisms underlying auditory hallucinations—understanding perception without stimulus
description	Auditory verbal hallucinations (AVH) are a common phenomenon, occurring in the “healthy” population as well as in several mental illnesses, most notably schizophrenia. Current thinking supports a spectrum conceptualisation of AVH: several neurocognitive hypotheses of AVH have been proposed, including the “feed-forward” model of failure to provide appropriate information to somatosensory cortices so that stimuli appear unbidden, and an “aberrant memory model” implicating deficient memory processes. Neuroimaging and connectivity studies are in broad agreement with these with a general dysconnectivity between frontotemporal regions involved in language, memory and salience properties. Disappointingly many AVH remain resistant to standard treatments and persist for many years. There is a need to develop novel therapies to augment existing pharmacological and psychological therapies: transcranial magnetic stimulation has emerged as a potential treatment, though more recent clinical data has been less encouraging. Our understanding of AVH remains incomplete though much progress has been made in recent years. We herein provide a broad overview and review of this.
publisher	MDPI
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061847/
_version_	1612102945134870528

Mechanisms Underlying Auditory Hallucinations—Understanding Perception without Stimulus

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