Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise

Mediators of monocyte migration, complement receptor-3 (CR3), and chemokine ligand-4 (CCL4) were measured in response to recovery modalities following resistance exercise. Thirty resistance-trained men (23.1 ± 2.9 y; 175.2 ± 7.1 cm; 82.1 ± 8.4 kg) were given neuromuscular electric stimulation (NMES)...

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Main Authors:	Jajtner, Adam R., Fragala, Maren S., Townsend, Jeremy R., Gonzalez, Adam M., Wells, Adam J., Fukuda, David H., Stout, Jeffrey R., Hoffman, Jay R.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060064/

id	pubmed-4060064
recordtype	oai_dc
spelling	pubmed-40600642014-07-01 Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise Jajtner, Adam R. Fragala, Maren S. Townsend, Jeremy R. Gonzalez, Adam M. Wells, Adam J. Fukuda, David H. Stout, Jeffrey R. Hoffman, Jay R. Research Article Mediators of monocyte migration, complement receptor-3 (CR3), and chemokine ligand-4 (CCL4) were measured in response to recovery modalities following resistance exercise. Thirty resistance-trained men (23.1 ± 2.9 y; 175.2 ± 7.1 cm; 82.1 ± 8.4 kg) were given neuromuscular electric stimulation (NMES), cold water immersion (CWI), or control (CON) treatments immediately following resistance exercise. Blood samples were obtained preexercise (PRE), immediately (IP), 30 minutes (30 P), 24 hours (24 H), and 48 hours (48 H) after exercise for measurement of circulating CCL4 and CR3 expression on CD14+ monocytes, by assay and flow cytometry. Circulating CCL4 showed no consistent changes. Inferential analysis indicated that CR3 expression was likely greater in CON at 30 P than NMES (90.0%) or CWI (86.8%). NMES was likely lower than CON at 24 H (92.9%) and very likely lower at 48 H (98.7%). Expression of CR3 following CWI was very likely greater than CON (96.5%) at 24 H. The proportion of CR3+ monocytes was likely greater following CWI than NMES (85.8%) or CON (85.2%) at 24 H. The change in proportion of CR3+ monocytes was likely (86.4%) greater following NMES than CON from IP to 30 P. The increased expression of CR3 and increased proportion of CR3+ monocytes following CWI at 24 H indicate a potentially improved ability for monocyte adhesion to the endothelium, possibly improving phagocytosis of damaged tissues. Hindawi Publishing Corporation 2014 2014-06-02 /pmc/articles/PMC4060064/ /pubmed/24987193 http://dx.doi.org/10.1155/2014/145817 Text en Copyright © 2014 Adam R. Jajtner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jajtner, Adam R. Fragala, Maren S. Townsend, Jeremy R. Gonzalez, Adam M. Wells, Adam J. Fukuda, David H. Stout, Jeffrey R. Hoffman, Jay R.
spellingShingle	Jajtner, Adam R. Fragala, Maren S. Townsend, Jeremy R. Gonzalez, Adam M. Wells, Adam J. Fukuda, David H. Stout, Jeffrey R. Hoffman, Jay R. Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
author_facet	Jajtner, Adam R. Fragala, Maren S. Townsend, Jeremy R. Gonzalez, Adam M. Wells, Adam J. Fukuda, David H. Stout, Jeffrey R. Hoffman, Jay R.
author_sort	Jajtner, Adam R.
title	Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
title_short	Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
title_full	Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
title_fullStr	Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
title_full_unstemmed	Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise
title_sort	mediators of monocyte migration in response to recovery modalities following resistance exercise
description	Mediators of monocyte migration, complement receptor-3 (CR3), and chemokine ligand-4 (CCL4) were measured in response to recovery modalities following resistance exercise. Thirty resistance-trained men (23.1 ± 2.9 y; 175.2 ± 7.1 cm; 82.1 ± 8.4 kg) were given neuromuscular electric stimulation (NMES), cold water immersion (CWI), or control (CON) treatments immediately following resistance exercise. Blood samples were obtained preexercise (PRE), immediately (IP), 30 minutes (30 P), 24 hours (24 H), and 48 hours (48 H) after exercise for measurement of circulating CCL4 and CR3 expression on CD14+ monocytes, by assay and flow cytometry. Circulating CCL4 showed no consistent changes. Inferential analysis indicated that CR3 expression was likely greater in CON at 30 P than NMES (90.0%) or CWI (86.8%). NMES was likely lower than CON at 24 H (92.9%) and very likely lower at 48 H (98.7%). Expression of CR3 following CWI was very likely greater than CON (96.5%) at 24 H. The proportion of CR3+ monocytes was likely greater following CWI than NMES (85.8%) or CON (85.2%) at 24 H. The change in proportion of CR3+ monocytes was likely (86.4%) greater following NMES than CON from IP to 30 P. The increased expression of CR3 and increased proportion of CR3+ monocytes following CWI at 24 H indicate a potentially improved ability for monocyte adhesion to the endothelium, possibly improving phagocytosis of damaged tissues.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060064/
_version_	1612102225444732928

Mediators of Monocyte Migration in Response to Recovery Modalities following Resistance Exercise

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