Pathogenesis and Causes of Premature Ovarian Failure: An Update
Premature ovarian failure (POF) affects 1% of young women. This condition has significant psychological sequelae and major health implications. POF seriously interferes with fertility and family planning. Diverse etiologies are associated with POF. Literature review related to the causes and pathoge...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Royan Institute
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059950/ |
| id |
pubmed-4059950 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-40599502014-06-24 Pathogenesis and Causes of Premature Ovarian Failure: An Update Ebrahimi, Mahbod Akbari Asbagh, Firoozeh Review Article Premature ovarian failure (POF) affects 1% of young women. This condition has significant psychological sequelae and major health implications. POF seriously interferes with fertility and family planning. Diverse etiologies are associated with POF. Literature review related to the causes and pathogenesis of POF, cited between the year 1900 and May 2010. POF may be either spontaneous or induced. The known causes include: Genetic disorders, which could involve the X chromosome or autosomes. However, the growing body of literature demonstrates a list of newly discovered mutations that may be responsible for causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered to be idiopathic.Autoimmune causes; there is some evidence of an association of POF with lymphocytic oophoritis and other autoimmune disorders. Antiovarian antibodies are reported in POF, but their specificity and pathogenic role are obscure.Iatrogenic causes; chemotherapy, radiotherapy and pelvic surgery can lead to POF.Infectious Causes; some viral and microbial infections can be followed by POF.Environmental toxins, such as cigarette smoking are reported as risk factors of spontaneous POF.Idiopathic; in most cases, no identifiable etiology can be recognized after complete evaluation. Royan Institute 2011 2011-09-23 /pmc/articles/PMC4059950/ /pubmed/24963360 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ebrahimi, Mahbod Akbari Asbagh, Firoozeh |
| spellingShingle |
Ebrahimi, Mahbod Akbari Asbagh, Firoozeh Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| author_facet |
Ebrahimi, Mahbod Akbari Asbagh, Firoozeh |
| author_sort |
Ebrahimi, Mahbod |
| title |
Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| title_short |
Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| title_full |
Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| title_fullStr |
Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| title_full_unstemmed |
Pathogenesis and Causes of Premature Ovarian Failure: An Update |
| title_sort |
pathogenesis and causes of premature ovarian failure: an update |
| description |
Premature ovarian failure (POF) affects 1% of young women. This condition has significant
psychological sequelae and major health implications. POF seriously interferes with fertility and
family planning. Diverse etiologies are associated with POF.
Literature review related to the causes and pathogenesis of POF, cited between the year 1900 and
May 2010.
POF may be either spontaneous or induced. The known causes include:
Genetic disorders, which could involve the X chromosome or autosomes. However, the growing
body of literature demonstrates a list of newly discovered mutations that may be responsible for
causing POF. Most of these mutations are extremely rare, and most cases of POF are still considered
to be idiopathic.Autoimmune causes; there is some evidence of an association of POF with lymphocytic oophoritis
and other autoimmune disorders. Antiovarian antibodies are reported in POF, but their specificity
and pathogenic role are obscure.Iatrogenic causes; chemotherapy, radiotherapy and pelvic surgery can lead to POF.Infectious Causes; some viral and microbial infections can be followed by POF.Environmental toxins, such as cigarette smoking are reported as risk factors of spontaneous POF.Idiopathic; in most cases, no identifiable etiology can be recognized after complete evaluation. |
| publisher |
Royan Institute |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059950/ |
| _version_ |
1612102180878155776 |